Impact of the COVID-19 pandemic on the hospitalization trends in a third level Child Neuropsychiatry Unit

Introduction: The COVID-19 outbreak and related confinement measures have disturbed the psychological well-being of young children and adolescents, especially in at-risk groups. Aim of the study was to evaluate the trend and severity of children' and adolescents' neuropsychiatric diseases in the context of a prolonged state of confinement measures. Materials and Methods: Data were retrospectively collected from all subjects aged between 4 and 16 years +/- 6 months, admitted to the Child Neuropsychiatry ward of the Gaslini Children Hospital between 01/01/20 and 30/05/21. Demographic and clinical characteristics were noted for each subject. Subjects were then divided in admitted before or after COVID outbreak, considered as the 9th Match 2020. Data of psychiatric patients about subjects' functioning (Children Global Assessment Scale, C-GAS) and disease severity (Global Impression- Severity, CGI-S) were collected. Results: Of 561 inpatients, 105 were admitted before the COVID-19 outbreak and 456 after, with an absolute increment of 30% for psychiatric diseases compared to neurological ones (33/105, 31.43% before vs. 187/456, 41.0% after;p = .013). For psychiatric diseases, there was an increase in the hospitalization duration (3.91 +/- 4.07 vs. 13.02 +/- 4.25;p = .04), an increase of subjects with previous neuropsychiatric disorders (27.7%, 9/33 vs. 47.7%, 89/187;p = .034), a decrease of CGAS scores (56,24 +/- 13,87 vs. 51,63 +/- 17,797;p = .050) and an increase disease severity worsening (CGI-S 3.76 +/- 1.12 vs. 4. 48 +/- 1.36;p = .006). In the female gender and in the ethnic minorities' subgroup, number of hospitalizations have statistically increased, with CGI-S and CGAS scores more impaired after the COVID-19 outbreak. On multivariate analysis, being female, having a previous psychiatric diagnosis, and belonging to an ethnic minority appeared to influence patients' overall impairment index (p < .005). Conclusions: The COVID-19 outbreak and the measures adopted to contain the virus spread had an impact on the severity of the course of psychiatric admissions, with greater influence on subjects who were already psychologically vulnerable, female, and who belonged to ethnic minorities. (PsycInfo Database Record (c) 2023 APA, all rights reserved) (Italian) Introduzione: Lo scoppio della pandemia da COVID-19 e le relative misure di confinamento hanno minato il benessere psicologico della popolazione in eta evolutiva, soprattutto nelle categorie a rischio. Scopo dello studio e stato quello di valutare andamento e gravita dei soggetti accolti per patologia neuropsichiatrica nel contesto di uno stato prolungato di prosecuzione di misure di contenimento del contagio. Materiali e metodi: Sono state retrospettivamente raccolti i dati di tutti i soggetti di eta compresa fra 4 e 16 anni +/- 6 mesi ricoverati presso la UO di Neuropsichiatria Infantile dell'Ospedale Gaslini tra lo 01/01/20 e il 30/05/21. Per ciascun caso sono state annotate le caratteristiche demografiche e cliniche. I soggetti sono stati divisi tra ricoverati prima e dopo l'inizio della pandemia, considerato come data il 9 marzo 2020. Per i casi psichiatrici sono state applicate scale di funzionamento Children Global Assessment Scale (C-GAS) e di gravita Global Imression-Severity (CGI-S). Risultati: Di 561 accessi, 105 sono avvenuti preCOVID e 456 postCOVID, con un incremento assoluto del 30% degli accessi per patologia psichiatrica rispetto a quella neurologica (33/105, 31,4% preCOVID vs 187/456, 41,0% postCOVID;p = ,013). Per la patologia psichiatrica, si e assistito ad un aumento dei giorni di ospedalizzazione (3,91 +/- 4,07 vs 13,02 +/- 4,25;p = ,04), un aumento dei soggetti con precedente diagnosi neuropsichiatrica (27,7%, 9/33 vs 47,7%, 89/187;p = ,034), una diminuzione dei punteggi CGAS (56,24 +/- 13,87 vs 51,63 +/- 17,797;p = ,050) ed un aumento della gravita di patologia (CGI-S 3,76 +/- 1,12 vs 4,48 +/- 1,36;p = ,006). Nel sottogruppo di soggetti di genere femminile e delle minoranze etniche, i ricoveri per patologia psichiatrica sono risultati significativamente aumentati con punteggi CGI-S e CGAS maggiormente compromessi dopo lo scoppio del COVID-19. All'analisi multivariata, il sesso femminile, una pregressa diagnosi psichiatrica e l'appartenenza a minoranze etniche appaiono avere un effetto sull'indice di compromissione globale dei pazienti (p < ,005). Conclusioni: La pandemia da COVID-19 e le misure adottate per contenere il contagio hanno impattato la gravita del decorso dei ricoveri neuropsichiatrici, con maggiore effetto su soggetti gia fragili, di genere femminile ed appartenenti a minoranze etniche. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Sleep disturbances in craniopharyngioma: a challenging diagnosis

Introduction: The hypothalamus plays a crucial role in regulating vital functions and circadian rhythms. Both the tumor involving the hypothalamic area and its treatment can lead to hypothalamic dysfunction, resulting in disturbances in sleep-wake patterns, sleep fragmentation, and increased daytime sleepiness. We describe two patients with craniopharyngioma who came to our attention due to the occurrence of episodes characterized by psychomotor slowing and afinalistic limb movements, temporal and spatial disorientation, psychomotor agitation, and oneiric stupor like episodes diagnosed as severe sleep disturbances. Case reports: Patient 1 is a 19-year-old male diagnosed with surgically treated craniopharyngioma. Subsequently, episodes of psychomotor slowing, afinalistic movements of the upper limbs diagnosed as seizures in another neurological center appeared;antiepileptic treatment was started without improvement. At the first examination in our center, excessive daytime sleepiness (EDS), fragmented nighttime sleep, episodes characterized by bimanual automatic gestures occurring during drowsy state, hypnagogic hallucinations, and sudden loss of muscle tone while awake were recognized. Actigraphy demonstrated irregular bedtimes, frequent nocturnal activity, and inappropriate daytime rest episodes. The Epworth Sleepiness Scale (ESS) showed subjective EDS (ESS=19). At PSG, hypersomnolence, severe sleep-related breathing disorder (SRBD), and no interictal and ictal seizure abnormalities were found. A BiPAP NIV was started, and antiepileptic therapy was discontinued. In the following months, PSG revealed marked improvement in SRBD and 1 SOREMP, and the MSLT a mean SOL of 6 min and 10 sec and 3 SOREMPs. These data allowed the diagnosis of secondary narcolepsy, and treatment with pitolisant was initiated with clinical improvement and reduced daytime sleepiness (ESS=9). Patient 2 is a 12-year-old male, surgically treated for craniopharyngioma at the age of 4 years, who developed episodes of myoclonic jerks, temporal and spatial disorientation, and psychomotor agitation during the lockdown period for COVID-19 emergency. Surmising paroxysmal epileptic episodes, the patient was hospitalized. The anamnestic data collection revealed a sleep-wake rhythm dysregulation, fragmented nighttime sleep, EDS, oneiric stupor-like episodes during which the patient performed simple automatic gestures mimicking daily-life activity, and severe impairment of alertness. The Long-term video-EEG, including polygraphic measurements, showed destruction of the wake-NREM sleep-REM sleep boundaries, episodes of undetermined state of vigilance, and concurrence of elements typical of different sleep stages. Moreover, a severe SRBD (AHI 19/h) has been observed. The MRI showed a volumetric increase in the post-surgical interpeduncular fossa and right paramedian cysts. Therefore, a multifactorial therapeutic plan including sleep hygiene and slow-release melatonin was started with improvement in nighttime sleep, but EDS persisted. Surgical treatment of cyst fenestration improved sleep-wake rhythm and behavior;BiPAP NIV was initiated with very poor adherence. Discussion: We aim to focus on sleep disorders as a possible complication of tumors involving the hypothalamic region. Our cases highlight that the clinical manifestation of these dysfunctions can be challenging to diagnose and can lead to misdiagnosis and inappropriate treatment that can harm patients' health and the quality of life of patients and their families. Conclusion: These findings support the need to incorporate comprehensive sleep assessment in survivors from childhood brain tumors involving the suprasellar/hypothalamic region.